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The Mechanism of ATP Synthesis
©1999 Timothy Paustian, University of Wisconsin-Madison
ATP synthase is driven by proton exchanges on subunit c. It is thought that when subunit c moves near subunit a, it interacts with it, losing a proton off an acidic amino acid. The released proton moves into the cytoplasm. A new proton from the periplasm enters through a channel in subunit a and interupts this interaction, causing subunit c to move away from subunit a and turning F1 relative to F0.
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